Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy
Shanghai University · Shanghai Research Institute of Materials · +2 more institutions
Abstract
Abstract Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots…
Citation impact
- FWCI
- 27.29
- Percentile
- 100%
- References
- 68
Authors
7Topics & keywords
- Sonodynamic therapy
- Phosphorescence
- Excited state
- Materials science
- Quantum dot
- Near-infrared spectroscopy
- Infrared
- Photochemistry
Funding
- NNNational Natural Science Foundation of ChinaAwards: 22108168, 22278262, 12175142, 22177067
- CPChina Postdoctoral Science FoundationAwards: ynms202103, 2020M681267
- SAScience and Technology Commission of Shanghai MunicipalityAwards: ynms202103, 22ZR1424000
- SJShanghai Jiao Tong UniversityAward: ynms202103
- SRShanghai Rising-Star ProgramAwards: No. 20QA1403400, 20QA1403400