Stroke genetics informs drug discovery and risk prediction across ancestries

Abstract Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry 1,2 . Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals,…

• MF
  McKnight Foundation
• MG
  Massachusetts General Hospital
• OS
  Ohio State University
• UO
  University of Minnesota
• UO
  University of Washington
• NT
  Norges Teknisk-Naturvitenskapelige Universitet
• AU
  Amsterdam University Medical Centers
• UO
  University of Bristol
• IN
  Institut National de la Santé et de la Recherche Médicale
• UL
  Universiteit Leiden
• UV
  Universiteit van Amsterdam
• UM
  Universiteit Maastricht
• MU
  Maastricht Universitair Medisch Centrum
• UO
  University of Tokyo
• LU
  Leids Universitair Medisch Centrum
• UM
  Universitair Medisch Centrum Groningen
• IN
  Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
• UO
  University of California, San Diego

  Award: 99,100
• CF
  Center for Clinical and Translational Science, Ohio State University
• MR
  Medical Research Council

  Awards: MC_PC_14135, MC_UU_00017/1, MC_PC_12029, MC_PC_12027, MC_PC_12028, MC_EX_G0801669, MR/S004130/1, MC_PC_13049
• SS
  Statens Serum Institut
• EU
  Erasmus Universitair Medisch Centrum Rotterdam
• FO
  Faculty of Medicine and Health, University of Sydney
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: U01 NS041588, NS041588