Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination
Chinese Academy of Sciences · Yantai Institute of Coastal Zone Research · +4 more institutions
Abstract
Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral discrimination strategy has not yet been developed because of the inevitable nonspecific binding entity of wrong enantiomers or insufficient intrinsic optical activities of chiral molecules. Here, we propose an "inspector" recognition mechanism (IRM), which is implemented on a chiral imprinted polydopamine (PDA) layer coated on surface-enhanced Raman scattering (SERS) tag layer. The IRM works based on the permeability change of the imprinted PDA after the chiral recognition and scrutiny of the permeability by an inspector molecule. Good enantiomer can specifically recognize and fully fill the chiral imprinted…
Citation impact
- FWCI
- 22.29
- Percentile
- 100%
- References
- 61
Authors
8- MAMaryam ArabiCorresponding
Chinese Academy of Sciences, Yantai Institute of Coastal Zone Research
- AOAbbas Ostovan
Chinese Academy of Sciences, Yantai Institute of Coastal Zone Research
- YWYunqing Wang
Chinese Academy of Sciences, Yantai Institute of Coastal Zone Research, Qingdao National Laboratory for Marine Science and Technology
- RMRongchao Mei
Chinese Academy of Sciences, Yantai Institute of Coastal Zone Research
- LFLongwen Fu
Chinese Academy of Sciences, Yantai Institute of Coastal Zone Research
Topics & keywords
- Enantiomer
- Chirality (physics)
- Molecule
- Molecular imprinting
- Molecular recognition
- Enantiomeric excess
- Chemistry
- Raman scattering
- Reduced inequalities
Funding
- NNNational Natural Science Foundation of ChinaAwards: ts20190962, YZ201662, 21876199, 42076199, 22176210, 2017256, 21976209, 21804010
- CAChinese Academy of SciencesAwards: 2017256, 2020PC0083, ts20190962, YZ201662, 21976209, 2019PC0050
- YIYouth Innovation Promotion Association of the Chinese Academy of SciencesAwards: 2017256, YZ201662, 21976209, ts20190962
- YIYouth Innovation Promotion AssociationAwards: 21976209, 2017256, YZ201662, ts20190962