Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.
University of North Carolina at Chapel Hill
Abstract
After the intracisternal administration of 6-hydroxydopamine, brain levels of norepinephrine were reduced significantly with or without pargyline pretreatment. Depletion of dopamine in the central nervous system was found to be enhanced markedly by pargyline administration at higher dose levels of 6-hydroxydopamine. Brain serotonin concentrations were not altered. The effects of 6-hydroxydopamine were long-lasting with the depletion of brain amines persisting at 78 days. After norepinephrine-H3 intracisternally to animals treated with 6-hydroxydopamine, labeled norepinephrine uptake was diminished with a corresponding reduction of deaminated catechols and a marked increased in methylated amines. Tyrosine…
Citation impact
- FWCI
- 0.94
- Percentile
- 98%
- References
- 0
Authors
2Topics & keywords
- Hydroxydopamine
- Dopamine
- Catecholamine
- Norepinephrine
- Neuroscience
- Oxidopamine
- Degeneration (medical)
- Chemistry
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