articleNature CommunicationsOct 2, 2022GOLD OA

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

PYPing YangHQHong QinYLYiyu LiAXAnhua XiaoEZEnze Zheng

Dalian Medical University · Second Affiliated Hospital of Chongqing Medical University · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-mediated immune suppression. Understanding the mechanisms leading to functional reprogramming of macrophages in the tumor microenvironment (TME) will benefit cancer immunotherapy. Herein, we find that the scavenger receptor CD36 is upregulated in metastasis-associated macrophages (MAMs) and deletion of CD36 in MAMs attenuates liver metastasis in mice. MAMs contain more lipid droplets and have the unique capability in engulfing tumor cell-derived long-chain fatty acids, which are carried by extracellular vesicles. The lipid-enriched vesicles are preferentially partitioned into macrophages via CD36, that fuel macrophages and…

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Topics & keywords

Topics
Keywords
  • CD36
  • Scavenger receptor
  • Metastasis
  • Tumor microenvironment
  • Cancer research
  • Immune system
  • Immunotherapy
  • Crosstalk
UN Sustainable Development Goals
  • Good health and well-being
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