Phenix - a comprehensive python-based system for macromolecular structure solution

Macromolecular X-ray crystallography is routinely applied to understand biological processes at a molecular level. However, significant time and effort are still required to solve and complete many of these structures because of the need for manual interpretation of complex numerical data using many software packages, and the repeated use of interactive three-dimensional graphics. Phenix has been developed to provide a comprehensive system for crystallographic structure solution with an emphasis on automation of all procedures. This has relied on the development of algorithms that minimize or eliminate subjective input, the development of algorithms that automate procedures that are traditionally performed by…

• UD
  U.S. Department of Energy

  Awards: DE-AC02-05CH, 11231, DE-AC02-05CH 11231, DE-AC02, DE-AC0, DE-AC02-
• WT
  Wellcome Trust
• NI
  National Institutes of Health
• NN
  National Nuclear Security Administration
• LA
  Los Alamos National Laboratory