Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis

Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the innate immune system. Studies have revealed the participation of the STING pathway in unregulated inflammatory processes, traumatic brain injury (TBI), spinal cord injury (SCI), subarachnoid haemorrhage (SAH) and hypoxic-ischaemic encephalopathy (HIE). STING signalling is markedly increased in CNS injury, and STING agonists might facilitate the pathogenesis of CNS injury. However, the effects of STING-regulated signalling activation in CNS injury are not well understood. Aberrant activation of STING increases inflammatory…

• NN
  National Natural Science Foundation of China

  Awards: LY17H060009, Y21H060050, Y20210438, 8207219, LGF20H150003
• WM
  Wenzhou Municipal Science and Technology Bureau
• NS
  Natural Science Foundation of Zhejiang Province

  Awards: No. LY17H060009, LY17H060009, LGF20H150003, Y20210438, Y21H060050, 8207219
• ZP
  Zhejiang Province Public Welfare Technology Application Research Project

  Award: LGF20H150003