Molecular pathways of major depressive disorder converge on the synapse
The University of Texas MD Anderson Cancer Center · The University of Texas Health Science Center · +3 more institutions
Abstract
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory and inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, the opioid system, myelination, and the gut-brain axis, among others. This review aims at illustrating how these multiple signaling pathways and systems may interact to provide a more comprehensive view of MDD's neurobiology. In particular, considering the pattern of…
Citation impact
- FWCI
- 25.12
- Percentile
- 100%
- References
- 260
Authors
4- GRGabriel R. FriesCorresponding
The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center, The University of Texas Health Science Center at Houston
- VSValeria Saldana
Quinnipiac University
- JFJohannes Finnstein
Max Planck Institute of Psychiatry
- TRTheo Rein
Max Planck Institute of Psychiatry
Topics & keywords
- Neuroscience
- Neurotransmission
- Major depressive disorder
- Psychology
- Synapse
- Neurogenesis
- Cognition
- Biology
- Good health and well-being