reviewJournal of HepatologyOct 6, 2022HYBRID OA

Mitochondrial alterations in fatty liver diseases

BFBernard FromentyMRMichael Roden

Inserm · Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · +6 more institutions

PubMed
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Abstract

Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic exposure and excessive alcohol use, all of which have been shown to exert toxic effects on hepatic mitochondrial functionality and dynamics. Invasive or complex methodology limits large-scale investigations of mitochondria in human livers. Nevertheless, abnormal mitochondrial function, such as impaired fatty acid oxidation and oxidative phosphorylation, drives oxidative stress and has been identified as an important feature of human steatohepatitis. On the other hand, hepatic mitochondria can be flexible and adapt to the ambient metabolic condition to prevent triglyceride and lipotoxin accumulation in obesity. Experience…

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388
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2

Topics & keywords

Topics
Keywords
  • Steatohepatitis
  • Fatty liver
  • Mitochondrion
  • Xenobiotic
  • Oxidative phosphorylation
  • Biology
  • Oxidative stress
  • Steatosis
UN Sustainable Development Goals
  • Good health and well-being
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