Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Broad Institute · Massachusetts General Hospital · +70 more institutions
Abstract
Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity…
Citation impact
- FWCI
- 68.78
- Percentile
- 100%
- References
- 84
Authors
152- WZWei ZhouCorresponding
Broad Institute, Massachusetts General Hospital
- MKMasahiro Kanai
Broad Institute, Harvard University, Massachusetts General Hospital, The University of Osaka
- KWKuan-Han Wu
University of Michigan
- HRHumaira Rasheed
University of Oslo, Norwegian University of Science and Technology, University of Bristol
- KTKristin Tsuo
Broad Institute, Massachusetts General Hospital
Topics & keywords
- Biobank
- Genome-wide association study
- Genetic association
- Disease
- Meta-analysis
- Data science
- Biology
- Computational biology
- Partnerships for the goals