articleNatureOct 12, 2022HYBRID OA

A saturated map of common genetic variants associated with human height

LYLoïc YengoSVSailaja VedantamEMEirini MarouliJSJulia SidorenkoEBEric Bartell

The University of Queensland · Broad Institute · +341 more institutions

PubMed
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Abstract

Abstract Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes 1 . Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased…

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  • Genetics
  • Biology
  • Evolutionary biology
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