PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality

Innate immunity is the first response to protect against pathogens and cellular insults. Pattern recognition receptors sense pathogen- and damage-associated molecular patterns and induce an innate immune response characterized by inflammation and programmed cell death (PCD). In-depth characterization of innate immune PCD pathways has highlighted significant cross-talk. Recent advances led to the identification of a unique inflammatory PCD modality called PANoptosis, which is regulated by multifaceted PANoptosome complexes that are assembled by integrating components from other PCD pathways. The totality of biological effects observed in PANoptosis cannot be accounted for by any other PCD pathway alone. In this…

• AL
  American Lebanese Syrian Associated Charities

  Awards: AI124346, AR056296, AI101935
• NI
  National Institutes of Health

  Awards: AR056296, CA253095, AI101935, AI124346, AI160179