Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix (ECM). Ferroptosis is a novel form of cell death characterized by the lethal accumulation of iron and lipid peroxidation, which is associated with many diseases. Our study addressed the potential role played by ferroptosis and iron accumulation in the progression of pulmonary fibrosis. We found that the inducers of pulmonary fibrosis and injury, namely, bleomycin (BLM) and lipopolysaccharide (LPS), induced ferroptosis of lung epithelial cells. Both the ferroptosis inhibitor liproxstatin-1 (Lip-1) and the iron chelator deferoxamine (DFO)…

• NN
  National Natural Science Foundation of China

  Awards: 82173244, 82022059
• NK
  National Key Research and Development Program of China

  Award: 2019YFC1316303
• KS
  Key Science and Technology Program of Shaanxi Province

  Award: 2020KJXX-055
• NS
  Natural Science Basic Research Program of Shaanxi Province

  Award: 2019ZY-CXPT-03-01