CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) sequences and resistance-conferring mutations to provide an informatics framework for annotation and interpretation of resistomes. As of version 3.2.4, CARD encompasses 6627 ontology terms, 5010 reference sequences, 1933 mutations, 3004 publications, and 5057 AMR detection models that can be used by the accompanying Resistance Gene Identifier (RGI) software to annotate genomic or metagenomic sequences. Focused curation enhancements since 2020 include expanded β-lactamase curation, incorporation of likelihood-based AMR mutations for Mycobacterium tuberculosis,…

• CS
  Cisco Systems
• GC
  Genome Canada
• MU
  McMaster University
• CF
  Canada Foundation for Innovation
• SF
  Simon Fraser University
• CS
  Cisco Systems Canada
• MG
  Michael G. DeGroote Institute for Infectious Disease Research, McMaster University
• CI
  Canadian Institutes of Health Research

  Awards: FRN 143215, PJT-159456
• NS
  Natural Sciences and Engineering Research Council of Canada
• IO
  Institute of Infection and Immunity