Architecture of the dynamic fungal cell wall
University of Exeter · Medical Research Council · +1 more institution
Abstract
The fungal cell wall is essential for growth and survival, and is a key target for antifungal drugs and the immune system. The cell wall must be robust but flexible, protective and shielding yet porous to nutrients and membrane vesicles and receptive to exogenous signals. Most fungi have a common inner wall skeleton of chitin and β-glucans that functions as a flexible viscoelastic frame to which a more diverse set of outer cell wall polymers and glycosylated proteins are attached. Whereas the inner wall largely determines shape and strength, the outer wall confers properties of hydrophobicity, adhesiveness, and chemical and immunological heterogeneity. The spatial organization and dynamic regulation of the…
Citation impact
- FWCI
- 37.49
- Percentile
- 100%
- References
- 145
Authors
2Topics & keywords
- Cell wall
- Chitin
- Bespoke
- Biology
- Cell biology
- Nanotechnology
- Materials science
- Chitosan
- Sustainable cities and communities