8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification

Abstract In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most vulnerable to producing 8-oxoguanine, which can pair with adenine. Because of this feature, 8-oxoguanine in DNA (8-oxo-dG) induces a G > T (C > A) mutation in cancers, which can be deleterious and thus actively repaired by DNA repair pathways. 8-Oxoguanine in RNA (o 8 G) causes problems in aberrant quality and translational fidelity, thereby it is subjected to the RNA decay pathway. In addition to oxidative damage, 8-oxo-dG serves as an epigenetic modification that affects transcriptional regulatory elements and other epigenetic…

• KU
  Korea University
• KI
  Korea Institute of Science and Technology
• NR
  National Research Foundation of Korea

  Award: NRF-2020R1A2C3013762
• KG
  KU-KIST Graduate School of Converging Science and Technology