AnimalTFDB 4.0: a comprehensive animal transcription factor database updated with variation and expression annotations
Huazhong University of Science and Technology · Union Hospital · +1 more institution
Abstract
Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate gene expression and play crucial roles in all kinds of biological processes. To keep up with new data and provide a more comprehensive resource for TF research, we updated the Animal Transcription Factor Database (AnimalTFDB) to version 4.0 (http://bioinfo.life.hust.edu.cn/AnimalTFDB4/) with up-to-date data and functions. We refined the TF family rules and prediction pipeline to predict TFs in genome-wide protein sequences from Ensembl. As a result, we predicted 274 633 TF genes and 150 726 transcription cofactor genes in AnimalTFDB 4.0 in 183 animal genomes, which are 86 more species than AnimalTFDB 3.0. Besides…
Citation impact
- FWCI
- 30.84
- Percentile
- 100%
- References
- 53
Authors
9- WSWen‐Kang Shen
Huazhong University of Science and Technology
- SCSi‐Yi Chen
Union Hospital, Huazhong University of Science and Technology
- ZGZi-Quan Gan
Huazhong University of Science and Technology
- YZYuzhu Zhang
Huazhong University of Science and Technology
- TYTao Yue
Huazhong University of Science and Technology
Topics & keywords
- Ensembl
- Biology
- Transcription factor
- Gene
- Database
- Genetics
- Computational biology
- Genome