Precuneus magnetic stimulation for Alzheimer’s disease: a randomized, sham-controlled trial
University of Ferrara · Italian Institute of Technology · +10 more institutions
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is emerging as a non-invasive therapeutic strategy in the battle against Alzheimer's disease. Alzheimer's disease patients primarily show alterations of the default mode network for which the precuneus is a key node. Here, we hypothesized that targeting the precuneus with TMS represents a promising strategy to slow down cognitive and functional decline in Alzheimer's disease patients. We performed a randomized, double-blind, sham-controlled, phase 2, 24-week trial to determine the safety and efficacy of precuneus stimulation in patients with mild-to-moderate Alzheimer's disease. Fifty Alzheimer's disease patients were randomly assigned in a 1:1 ratio to…
Citation impact
- FWCI
- 18.19
- Percentile
- 100%
- References
- 57
Authors
16- GKGiacomo KochCorresponding
University of Ferrara, Italian Institute of Technology, Center for Translational Neurophysiology of Speech and Communication, Fondazione Santa Lucia
- EPElias Paolo Casula
Fondazione Santa Lucia
- SBSonia Bonnı̀
Fondazione Santa Lucia
- IBIlaria Borghi
Fondazione Santa Lucia
- MAMartina Assogna
University of Rome Tor Vergata, Fondazione Santa Lucia
Topics & keywords
- Precuneus
- Transcranial magnetic stimulation
- Dementia
- Alzheimer's disease
- Psychology
- Medicine
- Randomized controlled trial
- Brain stimulation