Diabetic Macular Edema: Current Understanding, Molecular Mechanisms and Therapeutic Implications
Shanghai Jiao Tong University · Shanghai Eye Disease Prevention & Treatment Center · +1 more institution
Abstract
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the main cause of vision impairment in diabetic patients, with its pathogenesis still not completely elucidated. Vascular endothelial growth factor (VEGF) plays a pivotal role in the pathogenesis of DR and DME. Currently, intravitreal injection of anti-VEGF agents remains as the first-line therapy in DME treatment due to the superior anatomic and functional outcomes. However, some patients do not respond satisfactorily to anti-VEGF injections. More than 30% patients still exist with persistent DME even after regular intravitreal injection…
Citation impact
- FWCI
- 41.42
- Percentile
- 100%
- References
- 253
Authors
10- JZJingfa ZhangCorresponding
Shanghai Jiao Tong University, Shanghai Eye Disease Prevention & Treatment Center, Shanghai First People's Hospital
- JZJingfa Zhang
Shanghai Jiao Tong University, Shanghai Eye Disease Prevention & Treatment Center, Shanghai First People's Hospital
- JZJingxiang Zhang
Shanghai Jiao Tong University, Shanghai Eye Disease Prevention & Treatment Center, Shanghai First People's Hospital
- JZJingxiang ZhangCorresponding
Shanghai Jiao Tong University, Shanghai Eye Disease Prevention & Treatment Center, Shanghai First People's Hospital
- CZChaoyang Zhang
Shanghai Jiao Tong University, Shanghai Eye Disease Prevention & Treatment Center, Shanghai First People's Hospital
Topics & keywords
- Pathogenesis
- Macular degeneration
- Medicine
- Diabetic retinopathy
- Neurodegeneration
- Bioinformatics
- Retinal pigment epithelium
- Retinal