FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations

Ferroptosis is a mode of regulated cell death characterized by iron-dependent accumulation of lipid peroxidation. It is closely linked to the pathophysiological processes in many diseases. Since our publication of the first ferroptosis database in 2020 (FerrDb V1), many new findings have been published. To keep up with the rapid progress in ferroptosis research and to provide timely and high-quality data, here we present the successor, FerrDb V2. It contains 1001 ferroptosis regulators and 143 ferroptosis-disease associations manually curated from 3288 articles. Specifically, there are 621 gene regulators, of which 264 are drivers, 238 are suppressors, 9 are markers, and 110 are unclassified genes; and there…

• NN
  National Natural Science Foundation of China

  Awards: 81802812, 81972658, 81803636
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2018A0303130329, 2018A030313129, 2019A1515012114