letterCancer DiscoveryOct 27, 2022BRONZE OA

Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

IMInés MarínOBOlga BoixAGAndrea García-GarijoISIsabelle SiroisACAdrià Caballé

Institute for Research in Biomedicine · Vall d'Hebron Institute of Oncology · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DC) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of IFN signaling, enhanced MHC class I machinery, and presentation of senescence-associated self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong antitumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells…

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321
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100%
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Authors

18

Topics & keywords

Topics
Keywords
  • Immune system
  • Senescence
  • CD8
  • Cytotoxic T cell
  • Biology
  • Antigen presentation
  • Acquired immune system
  • Cancer cell
UN Sustainable Development Goals
  • Good health and well-being
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