Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth…

• AE
  American Epilepsy Society
• MU
  McGill University
• NI
  National Institute of Academic Anaesthesia
• SF
  Savoy Foundation
• NI
  National Institute for Health and Care Research

  Award: BRC-1215-20014
• RC
  Royal College of Anaesthetists
• CR
  Canada Research Chairs
• NN
  Novo Nordisk
• CF
  Canada First Research Excellence Fund
• ES
  Epilepsy Society
• CI
  Canadian Institutes of Health Research

  Awards: 93614, MOP-93614
• NS
  Natural Sciences and Engineering Research Council of Canada

  Award: 017-04265
• MR
  Medical Research Council

  Awards: MR/K02308X/1, MR/L013215/1, MR/K02308X/1, BRC-1215-20014, MR/L013215/1
• NC
  NIHR Cambridge Biomedical Research Centre

  Award: BRC-1215-20014