reviewChemical ReviewsNov 1, 2022HYBRID OA

Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies

NANikhil AggarwalSKShohei KitanoGRGinette Ru Ying PuahSKSandra KittelmannIYIn Young Hwang

National University of Singapore · Wilmar International (Singapore) · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

The human microbiome is composed of a collection of dynamic microbial communities that inhabit various anatomical locations in the body. Accordingly, the coevolution of the microbiome with the host has resulted in these communities playing a profound role in promoting human health. Consequently, perturbations in the human microbiome can cause or exacerbate several diseases. In this Review, we present our current understanding of the relationship between human health and disease development, focusing on the microbiomes found across the digestive, respiratory, urinary, and reproductive systems as well as the skin. We further discuss various strategies by which the composition and function of the human microbiome…

Citation impact

436
total citations
FWCI
31.10
Percentile
100%
References
482
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Microbiome
  • Human microbiome
  • Coevolution
  • Function (biology)
  • Human health
  • Computational biology
  • Human Microbiome Project
  • Reprogramming
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