BCL-2 protein family: attractive targets for cancer therapy
The University of Melbourne · Walter and Eliza Hall Institute of Medical Research
Abstract
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling apoptotic cell death. Abnormal over-expression of pro-survival BCL-2 family members or abnormal reduction of pro-apoptotic BCL-2 family proteins, both resulting in the inhibition of apoptosis, are frequently detected in diverse malignancies. The critical role of the pro-survival and pro-apoptotic BCL-2 family proteins in the regulation of apoptosis makes them attractive targets for the development of agents for the treatment of cancer. This review describes the roles of the various pro-survival and pro-apoptotic members of the BCL-2 protein family in normal development and organismal…
Citation impact
- FWCI
- 36.55
- Percentile
- 100%
- References
- 254
Authors
4- DKDeeksha KaloniCorresponding
The University of Melbourne, Walter and Eliza Hall Institute of Medical Research
- STSarah T. Diepstraten
Walter and Eliza Hall Institute of Medical Research
- ASAndreas Strasser
The University of Melbourne, Walter and Eliza Hall Institute of Medical Research
- GLGemma L. Kelly
The University of Melbourne, Walter and Eliza Hall Institute of Medical Research
Topics & keywords
- Bcl-2 family
- Cancer
- Cancer therapy
- Apoptosis
- Computational biology
- Biology
- Cancer research
- Genetics
- Good health and well-being