articleNature Structural & Molecular BiologyNov 1, 2022HYBRID OA

A structural biology community assessment of AlphaFold2 applications

MAMehmet AkdelDEDouglas E. V. PiresEPEduard Porta‐PardoJJJürgen JänesAOArthur O. Zalevsky

Wageningen University & Research · The University of Melbourne · +20 more institutions

PubMed
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Abstract

Most proteins fold into 3D structures that determine how they function and orchestrate the biological processes of the cell. Recent developments in computational methods for protein structure predictions have reached the accuracy of experimentally determined models. Although this has been independently verified, the implementation of these methods across structural-biology applications remains to be tested. Here, we evaluate the use of AlphaFold2 (AF2) predictions in the study of characteristic structural elements; the impact of missense variants; function and ligand binding site predictions; modeling of interactions; and modeling of experimental structural data. For 11 proteomes, an average of 25% additional…

Citation impact

705
total citations
FWCI
56.31
Percentile
100%
References
90
Citations per year

Authors

34

Topics & keywords

Topics
Keywords
  • Structural biology
  • Computational biology
  • Biology
  • Chemistry
  • Cell biology
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