Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

Ossenkoppele, Rik; Binette, Alexa Pichet; Groot, Colin; Smith, Ruben; Strandberg, Olof; Palmqvist, Sebastian; Stomrud, Erik; Tideman, Pontus; Ohlsson, Tomas; Jögi, Jonas; Johnson, Keith A.; Sperling, Reisa A.; Doré, Vincent; Masters, Colin L.; Rowe, Christopher C.; Visser, Denise; Berckel, Bart N. M. van; Flier, Wiesje M. van der; Baker, Suzanne L.; Jagust, William J.; Wiste, Heather J.; Petersen, Ronald C.; Jack, Clifford R.; Hansson, Oskar

doi:10.1038/s41591-022-02049-x

articleNature MedicineNov 1, 2022HYBRID OA

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

RORik Ossenkoppele APAlexa Pichet Binette CGColin Groot RSRuben Smith OSOlof Strandberg

Lund University · Amsterdam Neuroscience · +15 more institutions

PubMed

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Abstract

Abstract A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer’s disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In this large multicenter amyloid and tau positron emission tomography (PET) study ( n = 1,325), we examined the risk for future progression to mild cognitive impairment and the rate of cognitive decline over time among cognitively unimpaired individuals who were amyloid PET-positive (A + ) and tau PET-positive (T + ) in the medial temporal lobe (A + T MTL + ) and/or in the temporal neocortex (A + T NEO-T + ) and…

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Topics & keywords

Topics

Keywords

Hazard ratio
Dementia
Cognitive decline
Positron emission tomography
Internal medicine
Medicine
Proportional hazards model
Amyloid (mycology)

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