articleCancer CellNov 10, 2022HYBRID OA

High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

SSStefan SalcherGSGregor SturmLHLena HorvathGUGerold UntergasserCKChristiane Kuempers

Universität Innsbruck · Tyrolean Cancer Research Institute · +6 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and resistance. However, full understanding of how immune cell phenotypes vary across different patient subgroups is lacking. Here, we dissect the NSCLC tumor microenvironment at high resolution by integrating 1,283,972 single cells from 556 samples and 318 patients across 29 datasets, including our dataset capturing cells with low mRNA content. We stratify patients into immune-deserted, B cell, T cell, and myeloid cell subtypes. Using bulk samples with genomic and clinical information, we identify cellular components associated with tumor…

Citation impact

444
total citations
FWCI
32.72
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100%
References
139
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Authors

21

Topics & keywords

Topics
Keywords
  • Biology
  • Cell
  • Single-cell analysis
  • Lung cancer
  • Diversity (politics)
  • Cell biology
  • Cancer research
  • Pathology
UN Sustainable Development Goals
  • Good health and well-being
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