The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
SIB Swiss Institute of Bioinformatics · University of Zurich · +7 more institutions
Abstract
Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information remains scattered across different database resources, experimental modalities and levels of mechanistic detail. The STRING database (https://string-db.org/) systematically collects and integrates protein-protein interactions-both physical interactions as well as functional associations. The data originate from a number of sources: automated text mining of the scientific literature, computational interaction predictions from co-expression, conserved genomic context, databases of…
Citation impact
- FWCI
- 633.65
- Percentile
- 100%
- References
- 73
Authors
13- DSDamian Szklarczyk
SIB Swiss Institute of Bioinformatics, University of Zurich
- RKRebecca Kirsch
University of Copenhagen, Novo Nordisk Foundation
- MKMikaela Koutrouli
University of Copenhagen, Novo Nordisk Foundation
- KNKaterina Nastou
University of Copenhagen, Novo Nordisk Foundation
- FMFarrokh Mehryary
University of Turku
Topics & keywords
- String (physics)
- Genome
- Biology
- Context (archaeology)
- Computational biology
- Interaction network
- Complement (music)
- Protein–protein interaction
Funding
- EMEuropean Molecular Biology Laboratory
- ECEuropean CommissionAward: 101023676
- AOAcademy of FinlandAwards: 332844, 332844
- UWUniversität Wien
- NNNovo NordiskAward: NNF14CC0001
- CSChina Scholarship Council
- UZUniversität Zürich
- NNNovo Nordisk FondenAwards: NNF20SA0035590, NNF14CC0001
- SISwiss Institute of Bioinformatics