CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1
Soochow University · First Affiliated Hospital of Soochow University
Abstract
Metastasis is an important factor contributing to poor prognosis in patients with gastric cancer; yet, the molecular mechanism leading to this cell behavior is still not well understood. In this study, we explored the role of cysteine protease inhibitor SN (Cystatin SN, CST1) in promoting gastric cancer metastasis. We hypothesized that CST1 could regulate gastric cancer progression by regulating GPX4 and ferroptosis. Whole transcriptome sequencing suggested that the expression of CST1 was significantly increased in metastatic cancer, and high CST1 expression was correlated with a worse prognosis. Our data further confirmed that the overexpression of CST1 may significantly promote the migration and invasion of…
Citation impact
- FWCI
- 41.85
- Percentile
- 100%
- References
- 43
Authors
13- DLDongbao LiCorresponding
Soochow University, First Affiliated Hospital of Soochow University
- YWYuhong Wang
Soochow University, First Affiliated Hospital of Soochow University
- CDChao Dong
Soochow University, First Affiliated Hospital of Soochow University
- TCTao Chen
Soochow University, First Affiliated Hospital of Soochow University
- ADAnqi Dong
Soochow University, First Affiliated Hospital of Soochow University
Topics & keywords
- Metastasis
- Cancer
- Cancer research
- Biology
- Cancer cell
- Immunology