Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms
University of Alabama at Birmingham · Research Network (United States) · +4 more institutions
Abstract
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using uniform standardized methods from start to end. We enrolled 490 PD and 234 control individuals, conducted deep shotgun sequencing of fecal DNA, followed by metagenome-wide association studies requiring significance by two methods (ANCOM-BC and MaAsLin2) to declare disease association, network analysis to identify polymicrobial clusters, and functional profiling. Here we show that over 30% of species, genes and pathways tested have altered abundances in PD, depicting a widespread dysbiosis. PD-associated species form polymicrobial…
Citation impact
- FWCI
- 33.42
- Percentile
- 100%
- References
- 76
Authors
8- ZDZachary D. WallenCorresponding
University of Alabama at Birmingham, Research Network (United States)
- ADAyşe Demirkan
University of Surrey
- GTGuy Twa
University of Alabama at Birmingham
- GCGwendolyn Cohen
University of Alabama at Birmingham, Research Network (United States)
- MDMarissa Dean
University of Alabama at Birmingham
Topics & keywords
- Microbiome
- Dysbiosis
- Metagenomics
- Disease
- Biology
- Gut microbiome
- Parkinson's disease
- Computational biology