Obesity and chronic kidney disease

The prevalence of obesity has increased dramatically during the past decades, which has been a major health problem. Since 1975, the number of people with obesity worldwide has nearly tripled. An increasing number of studies find obesity as a driver of chronic kidney disease (CKD) progression, and the mechanisms are complex and include hemodynamic changes, inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system (RAAS). Obesity-related kidney disease is characterized by glomerulomegaly, which is often accompanied by localized and segmental glomerulosclerosis lesions. In these patients, the early symptoms are atypical, with microproteinuria being the main clinical manifestation…

• BC
  Bethune Charitable Foundation

  Award: G2017044
• NN
  National Natural Science Foundation of China

  Award: 81972372
• DO
  Department of Science and Technology of Jilin Province

  Award: 20190303152SF
• JS
  Jilin Scientific and Technological Development Program

  Award: 20190201034JC
• FH
  First Hospital of Jilin University

  Award: JDYYZH-2102030