MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

Terlouw, Barbara R.; Blin, Kai; Navarro-Muñoz, Jorge C.; Avalon, Nicole E.; Chevrette, Marc G.; Egbert, Susan; Lee, Sang Hyeon; Meijer, David; Recchia, Michael J. J.; Reitz, Zachary L.; Santen, Jeffrey A. van; Sélem‐Mójica, Nelly; Tørring, Thomas; Zaroubi, Liana; Alanjary, Mohammad; Aleti, Gajender; Aguilar, César; Al-Salihi, Suhad A. A.; Augustijn, Hannah E.; Avelar‐Rivas, J. Abraham; Avitia-Dominguez, Luis Alfredo; Barona‐Gómez, Francisco; Bernaldo-Agüero, Jordan; Bielinski, Vincent A.; Biermann, Friederike; Booth, Thomas; Carrión, Víctor J.; Castelo‐Branco, Raquel; Chagas, Fernanda O.; Cruz‐Morales, Pablo; Du, Chao; Duncan, Katherine; Gavriilidou, Athina; Gayrard, Damien; Gutiérrez-García, Karina; Haslinger, Kristina; Helfrich, Eric J. N.; Hooft, Justin J. J. van der; JATI, AFIF PRANAYA; Kalkreuter, Edward; Kalyvas, Nikolaos; Kang, Kyo Bin; Kautsar, Satria A.; Kim, Wonyong; Kunjapur, Aditya M.; Li, Yong‐Xin; Lin, Geng-Min; Loureiro, Catarina; Louwen, Joris J. R.; Louwen, Nico L L; Lund, George; Parra, Jonathan; Philmus, Benjamin; Pourmohsenin, Bita; Pronk, Lotte J. U.; Rego, Adriana; Balaya, Rex Devasahayam Arokia; Robinson, Serina L.; Rosas-Becerra, Luis Rodrigo; Roxborough, Eve Tallulah; Schorn, Michelle; Scobie, Darren; Singh, Kumar Saurabh; Sokolova, Nika; Tang, Xiaoyu; Udwary, Daniel; Vigneshwari, Aruna; Vind, Kristiina; Vromans, Sophie P. J. M.; Waschulin, Valentin; Williams, Sam E.; Winter, Jaclyn M.; Witte, Thomas E.; Xie, Huali; Yang, Dong; Yu, Jingwei; Zdouc, Mitja M.; Zhong, Zheng; Collemare, Jérôme; Linington, Roger G.; Weber, Tilmann; Medema, Marnix H.

doi:10.1093/nar/gkac1049

articleNucleic Acids ResearchNov 18, 2022GOLD OA

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

BRBarbara R. Terlouw KBKai Blin JCJorge C. Navarro-Muñoz NENicole E. Avalon MGMarc G. Chevrette

Wageningen University & Research · Novo Nordisk Foundation · +55 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protection agents and biomaterials. The genes that encode these pathways are often organised into biosynthetic gene clusters (BGCs). In 2015, we defined the Minimum Information about a Biosynthetic Gene cluster (MIBiG): a standardised data format that describes the minimally required information to uniquely characterise a BGC. We simultaneously constructed an accompanying online database of BGCs, which has since been widely used by the community as a reference dataset for BGCs and…

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Biology
Gene
Computational biology
Genetics

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