articleNucleic Acids ResearchNov 18, 2022GOLD OA

eggNOG 6.0: enabling comparative genomics across 12 535 organisms

AHAna Hernández-PlazaDSDamian SzklarczykJBJorge BotasCPCarlos P. CantalapiedraJGJoaquín Giner‐Lamia

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · Centre for Plant Biotechnology and Genomics · +11 more institutions

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Abstract

The eggNOG (evolutionary gene genealogy Non-supervised Orthologous Groups) database is a bioinformatics resource providing orthology data and comprehensive functional information for organisms from all domains of life. Here, we present a major update of the database and website (version 6.0), which increases the number of covered organisms to 12 535 reference species, expands functional annotations, and implements new functionality. In total, eggNOG 6.0 provides a hierarchy of over 17M orthologous groups (OGs) computed at 1601 taxonomic levels, spanning 10 756 bacterial, 457 archaeal and 1322 eukaryotic organisms. OGs have been thoroughly annotated using recent knowledge from functional databases, including…

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Topics
Keywords
  • Biology
  • UniProt
  • Phylogenetic tree
  • KEGG
  • Phylogenetics
  • Computational biology
  • Genomics
  • Phylum
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