Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity
Goethe University Frankfurt · Georg Speyer Haus · +3 more institutions
Abstract
Tumor-associated inflammation (TAI) is a feature of essentially all cancers and can confer both tumor-promoting and -suppressive functions. Cancer-associated fibroblasts (CAF) comprise one very heterogeneous cellular component of the tumor microenvironment characterized by a high degree of plasticity. Recent single-cell sequencing analyses revealed distinct CAF populations in various human cancers and helped to define key CAF subtypes, such as myofibroblastic, inflammatory, and antigen-presenting CAFs, with the first two being present in virtually all tumors. Importantly, these three CAF populations are involved in and modulate the positive and negative consequences of TAI. The remarkable plasticity of CAFs…
Citation impact
- FWCI
- 21.84
- Percentile
- 100%
- References
- 80
Authors
4- KBKilian B. Kennel
Goethe University Frankfurt, Georg Speyer Haus, Frankfurt Cancer Institute
- MBMüge Bozlar
Goethe University Frankfurt, Georg Speyer Haus, Frankfurt Cancer Institute
- AFAdalbert F. De Valk
Goethe University Frankfurt, Georg Speyer Haus, Frankfurt Cancer Institute
- FRFlorian R. GretenCorresponding
Goethe University Frankfurt, German Cancer Research Center, Heidelberg University, Georg Speyer Haus, Frankfurt Cancer Institute
Topics & keywords
- Cancer-Associated Fibroblasts
- Inflammation
- Tumor microenvironment
- Cancer
- Context (archaeology)
- Immunotherapy
- Biology
- Cancer research
- Life in Land
Funding
- DFDeutsche ForschungsgemeinschaftAwards: SFB1292-Project ID: 318346496-TP16, Project ID: 441891347, SFB1479-Project ID: 441891347-P02, SFB1479, Gr1916/11-1, 441891347, GRK2336, SFB1292, 318346496, FOR 2438, FOR2438
- BFBundesministerium für Gesundheit
- HMHessisches Ministerium für Wissenschaft und KunstAward: III L 5 - 519/03/03.001 - (0015)
- SDStudienstiftung des Deutschen Volkes