Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Abstract Background Several recent observational studies have reported that gut microbiota composition is associated with preeclampsia. However, the causal effect of gut microbiota on preeclampsia-eclampsia is unknown. Methods A two-sample Mendelian randomization study was performed using the summary statistics of gut microbiota from the largest available genome-wide association study meta-analysis ( n =13,266) conducted by the MiBioGen consortium. The summary statistics of preeclampsia-eclampsia were obtained from the FinnGen consortium R7 release data (5731 cases and 160,670 controls). Inverse variance weighted, maximum likelihood, MR-Egger, weighted median, weighted model, MR-PRESSO, and cML-MA were used to…

• MS
  Medical Science and Technology Foundation of Guangdong Province

  Award: C2019090
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2019A1515111011