UniProt: the Universal Protein Knowledgebase in 2023

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this publication we describe enhancements made to our data processing pipeline and to our website to adapt to an ever-increasing information content. The number of sequences in UniProtKB has risen to over 227 million and we are working towards including a reference proteome for each taxonomic group. We continue to extract detailed annotations from the literature to update or create reviewed entries, while unreviewed entries are supplemented with annotations provided by automated systems using a variety of machine-learning…

• SE
  Spine Education and Research Institute
• EM
  European Molecular Biology Laboratory
• NI
  National Institutes of Health

  Award: U24HG007822
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/T010541/1, BB/S01781X/1, BB/S01781X/1, BB/T010541/1
• NI
  National Institute on Aging
• NH
  National Heart, Lung, and Blood Institute
• NH
  National Human Genome Research Institute
• NE
  National Eye Institute
• NC
  National Cancer Institute
• NI
  National Institute of General Medical Sciences
• NI
  National Institute of Allergy and Infectious Diseases
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases