reviewMilitary Medical ResearchNov 18, 2022DIAMOND OA

The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

YXYuan XiongBMBobin MiZLZe LinYHYiqiang HuLYLe Yu

Union Hospital · Wuhan University · +16 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone, cartilage, and soft tissue regeneration, effective clinical translation of these mechanisms remains a challenge. Regulation of the immune microenvironment is increasingly becoming a favorable target for bone, cartilage, and soft tissue regeneration; therefore, an in-depth understanding of the communication between immune cells and functional tissue cells would be valuable. Herein, we…

Citation impact

269
total citations
FWCI
38.89
Percentile
100%
References
301
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Authors

14

Topics & keywords

Topics
Keywords
  • Cartilage
  • Immune system
  • Regeneration (biology)
  • Medicine
  • Cell biology
  • Crosstalk
  • Immunology
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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