Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
Chinese Academy of Sciences · Ji Hua Laboratory · +5 more institutions
Abstract
TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed "gain-of-function". Emerging evidence suggests that mutp53 is highly associated with advanced malignancies and poor prognosis, which makes it a target for development of novel cancer therapies. Herein, we provide a summary of our knowledge of the mutp53 types and mutp53 spectrum in cancers. The mechanisms of mutp53 accumulation and gain-of-function are also summarized. Furthermore, we discuss the gain-of-function of mutp53 in cancers: genetic instability, ferroptosis, microenvironment,…
Citation impact
- FWCI
- 40.35
- Percentile
- 100%
- References
- 178
Authors
13- XCXiaohua ChenCorresponding
Chinese Academy of Sciences, Ji Hua Laboratory, Institute of Modern Physics, University of Chinese Academy of Sciences
- TZTaotao Zhang
Chinese Academy of Sciences, Institute of Modern Physics, University of Chinese Academy of Sciences
- WSWei Su
Chinese Academy of Sciences, Institute of Modern Physics, University of Chinese Academy of Sciences
- ZDZhihui Dou
Chinese Academy of Sciences, Institute of Modern Physics, University of Chinese Academy of Sciences
- DZDapeng Zhao
Chinese Academy of Sciences, Institute of Modern Physics, University of Chinese Academy of Sciences
Topics & keywords
- Suppressor
- Mechanism (biology)
- Biology
- Cancer
- Function (biology)
- Mutant
- Cancer research
- Gain of function
- Good health and well-being