Carboxylic Acids as Adaptive Functional Groups in Metallaphotoredox Catalysis

ConspectusThe development of palladium-catalyzed cross-coupling methods for the activation of C(sp2)–Br bonds facilitated access to arene-rich molecules, enabling a concomitant increase in the prevalence of this structural motif in drug molecules in recent decades. Today, there is a growing appreciation of the value of incorporating saturated C(sp3)-rich scaffolds into pharmaceutically active molecules as a means to achieve improved solubility and physiological stability, providing the impetus to develop new coupling strategies to access these challenging motifs in the most straightforward way possible. As an alternative to classical two-electron chemistry, redox chemistry can enable access to elusive…

• P
  Pfizer
• C
  Celgene
• PU
  Princeton University
• DA
  Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften
• NI
  National Institutes of Health

  Award: R35GM134897
• G
  Genentech
• NI
  National Institute of General Medical Sciences

  Award: R35GM134897