A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Abstract Although growth factor (GF)‐loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart hydrogels with excellent gelation/mechanical properties as well as controllable GF releasing capability. Herein, the incorporation of bone morphogenetic protein 2 (BMP‐2)‐functionalized MgFe‐layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) hydrogels loaded with platelet‐derived growth factor‐BB (PDGF‐BB) to construct a smart injectable thermo‐responsive hydrogel (denoted as CSP‐LB), which can achieve a burst release of PDGF‐BB and a sustained release of BMP‐2, for highly efficient bone regeneration is reported. The…

• NN
  National Natural Science Foundation of China

  Awards: 52122002, 81630064, 81871786, 21971007
• UO
  University of Hong Kong
• NS
  Natural Science Foundation of Beijing Municipality

  Award: 2212044