reviewCancer CommunicationsNov 24, 2022GOLD OA

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

ZFZengli FangQMQingcai MengJXJin XuWWWei WangBZBo Zhang

Shanghai Medical College of Fudan University · Fudan University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

As a critical component of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) play important roles in cancer initiation and progression. Well-known signaling pathways, including the transforming growth factor-β (TGF-β), Hedgehog (Hh), Notch, Wnt, Hippo, nuclear factor kappa-B (NF-κB), Janus kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)/AKT pathways, as well as transcription factors, including hypoxia-inducible factor (HIF), heat shock transcription factor 1 (HSF1), P53, Snail, and Twist, constitute complex regulatory networks in the TME to modulate the formation, activation, heterogeneity,…

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253
total citations
FWCI
18.71
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100%
References
405
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Authors

11

Topics & keywords

Topics
Keywords
  • Tumor microenvironment
  • Wnt signaling pathway
  • PI3K/AKT/mTOR pathway
  • Cancer research
  • Biology
  • Signal transduction
  • Transcription factor
  • Cell biology
UN Sustainable Development Goals
  • Good health and well-being
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