reviewThe LancetNov 25, 2022HYBRID OA

Systemic sclerosis

University of California, Los Angeles · Lund University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our treatment armamentarium. Early and accurate diagnosis is essential, while ongoing efforts to risk stratify patients have a central role in predicting both organ involvement and disease progression. A holistic approach is required when choosing the optimal therapeutic strategy, balancing the side-effect profile with efficacy and tailoring the treatment according to the goals of care of the patient. This Seminar reviews the…

Citation impact

530
total citations
FWCI
65.53
Percentile
100%
References
195
Citations per year

Authors

3

Topics & keywords

Keywords
  • Medicine
  • Scleroderma (fungus)
  • Disease
  • Intensive care medicine
  • Pathological
  • Systemic disease
  • Connective tissue disease
  • Fibrosis
UN Sustainable Development Goals
  • Good health and well-being
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