Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Technical University of Denmark · Centre for Immunity, Infection and Evolution · +149 more institutions
Abstract
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking…
Citation impact
- FWCI
- 12.27
- Percentile
- 100%
- References
- 59
Authors
264Topics & keywords
- Antibiotic resistance
- Antimicrobial
- Biology
- Resistance (ecology)
- Drug resistance
- Computational biology
- Genetics
- Biotechnology
- Clean water and sanitation
Funding
- SRSight Research UKAwards: NE/N020626/1, NE/V010441/1
- ECEuropean CommissionAward: 874735
- NNNovo Nordisk
- NNNovo Nordisk FondenAward: NNF16OC0021856
- DSDrainage Services Department
- H2Horizon 2020 Framework ProgrammeAward: 874735
- MRMedical Research CouncilAward: MR/P028195/1
- NENatural Environment Research CouncilAwards: NE/V010441/1, NE/N020626/1