The Role of Oxidative Stress in Atherosclerosis
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Abstract
Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen species (ROS) leads to a state of oxidative stress which is a major risk factor for the development and progression of atherosclerosis. ROS are important for maintaining vascular health through their potent signalling properties. However, ROS also activate pro-atherogenic processes such as inflammation, endothelial dysfunction and altered lipid metabolism. As such, considerable efforts have been made to identify and characterise sources of oxidative stress in blood vessels. Major enzymatic sources of vascular ROS include NADPH oxidases,…
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3Topics & keywords
Topics
Keywords
- Oxidative stress
- Reactive oxygen species
- Endothelial dysfunction
- Antioxidant
- Xanthine oxidase
- NADPH oxidase
- Inflammation
- Reactive nitrogen species
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