Organoids
National University of Singapore · Center for Excellence in Molecular Cell Science · +4 more institutions
Abstract
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. They can be dissected and interrogated for fundamental mechanistic studies on development, regeneration and repair in human tissues, and can also be used in diagnostics, disease modelling, drug discovery and personalized medicine. Organoids are derived from either pluripotent or tissue-resident stem (embryonic or adult) or progenitor or differentiated cells from healthy or diseased tissues, such as tumours. To date, numerous organoid engineering strategies that support organoid culture and growth, proliferation, differentiation and…
Citation impact
- FWCI
- 63.00
- Percentile
- 100%
- References
- 254
Authors
14- ZZZixuan ZhaoCorresponding
National University of Singapore
- XCXinyi Chen
Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences
- AMAnna M. Dowbaj
Max Planck Institute of Molecular Cell Biology and Genetics
- ASAleksandra Sljukic
Max Planck Institute of Molecular Cell Biology and Genetics
- KMKaitlin M. Bratlie
Iowa State University
Topics & keywords
- Organoid
- Induced pluripotent stem cell
- Embryonic stem cell
- Regenerative medicine
- Biology
- Stem cell
- Tissue engineering
- Cell biology
- Good health and well-being