Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
Jilin University · Chinese Academy of Sciences · +2 more institutions
Abstract
Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments for diabetic chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in chronic wounds is the primary difference between diabetic chronic wounds and normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) for chronic wound healing of diabetic rats through integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species to modulate the oxidative stress…
Citation impact
- FWCI
- 18.24
- Percentile
- 100%
- References
- 65
Authors
9- DCDaiyong Chao
Jilin University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- QDQingfeng Dong
Jilin University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- ZYZhixuan Yu
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- DQDesheng Qi
Jilin University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- MLMinghua Li
Jilin University, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Chemistry
- Chronic wound
- Inflammation
- Oxidative stress
- Reactive oxygen species
- Diabetes mellitus
- Wound healing
- Pharmacology
- Good health and well-being