Gut microbiome-wide association study of depressive symptoms
Erasmus MC · Amsterdam University Medical Centers · +4 more institutions
Abstract
Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and validate these findings in the Amsterdam HELIUS cohort in 1,539 subjects. We identify association of thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and…
Citation impact
- FWCI
- 36.12
- Percentile
- 100%
- References
- 95
Authors
12Topics & keywords
- Microbiome
- Depression (economics)
- Cohort
- Butyrate
- Biology
- Medicine
- Bioinformatics
- Internal medicine