reviewJournal of Hematology & OncologyDec 8, 2022GOLD OA

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

XTXuhui TongRTRong TangMXMingming XiaoJXJin XuWWWei Wang

Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target for the development of cancer medications in recent years. However, because tumor cells show avoidance to apoptosis, which causes treatment resistance and recurrence, numerous studies have been devoted to alternative cancer cell mortality processes, namely necroptosis, pyroptosis, ferroptosis, and cuproptosis; these RCD modalities have been extensively studied and…

Citation impact

811
total citations
FWCI
111.20
Percentile
100%
References
357
Citations per year

Authors

9

Topics & keywords

Topics
Keywords
  • Necroptosis
  • Pyroptosis
  • Programmed cell death
  • Tumor microenvironment
  • Cancer cell
  • Cancer research
  • Cancer
  • Metastasis
UN Sustainable Development Goals
  • Good health and well-being
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