Endoplasmic reticulum stress-mediated cell death in liver injury

The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse external stimuli. It has been established that ERS can induce different cell death modes, including autophagy, apoptosis, ferroptosis, and pyroptosis, through three major transmembrane receptors on the ER membrane, including inositol requirement enzyme 1α, protein kinase-like endoplasmic reticulum kinase and activating transcription factor 6. These different modes of cell death play an important role in the occurrence and development of various diseases, such as…

• MO
  Ministry of Science and Technology of the People's Republic of China

  Award: 2020ZYD058
• DO
  Department of Science and Technology of Sichuan Province

  Award: 2020ZYD058
• SP
  Sichuan Province Science and Technology Support Program

  Award: 2020YFN0152