GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels
Wuhan University of Science and Technology · Huazhong University of Science and Technology
Abstract
Cancer initiation and progression are likely caused by the dysregulation of biological pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify potential biological insights on the gene set level. However, platforms exploring cancer multi-omics data using GSA methods are lacking. In this study, we upgraded our GSCALite to GSCA (gene set cancer analysis, http://bioinfo.life.hust.edu.cn/GSCA) for cancer GSA at genomic, pharmacogenomic and immunogenomic levels. In this improved GSCA, we integrated expression, mutation, drug sensitivity and clinical data from four public data sources for 33 cancer types. We introduced useful features to GSCA, including associations between immune…
Citation impact
- FWCI
- 43.48
- Percentile
- 100%
- References
- 23
Authors
7- CLChunjie Liu
Wuhan University of Science and Technology, Huazhong University of Science and Technology
- FHFeifei Hu
Wuhan University of Science and Technology
- GXGui‐Yan Xie
Huazhong University of Science and Technology
- YMYa‐Ru Miao
Huazhong University of Science and Technology
- XLXinwen Li
Wuhan University of Science and Technology
Topics & keywords
- Pharmacogenomics
- Biology
- Gene
- Computational biology
- Gene expression
- Cancer
- KEGG
- Gene expression profiling